# name
Screening for an ivermectin slow-release formulation suitable
                for malaria vector control

# metadata.dc.description.abstract[].value
BACKGROUND: The prospect of eliminating malaria is challenged by
                emerging insecticide resistance and vectors with outdoor and/or
                crepuscular activity. Ivermectin can simultaneously tackle these
                issues by killing mosquitoes feeding on treated animals and
                humans. A single oral dose, however, confers only short-lived
                mosquitocidal plasma levels. METHODS: Three different
                slow-release formulations of ivermectin were screened for their
                capacity to sustain mosquito-killing levels of ivermectin for
                months. Thirty rabbits received a dose of one, two or three
                silicone implants containing different proportions of
                ivermectin, deoxycholate and sucrose. Animals were checked for
                toxicity and ivermectin was quantified periodically in blood.
                Potential impact of corresponding long-lasting formulation was
                mathematically modelled. RESULTS: All combinations of
                formulation and dose released ivermectin for more than 12 weeks;
                four combinations sustained plasma levels capable of killing 50%
                of Anopheles gambiae feeding on a treated subject for up to 24
                weeks. No major adverse effects attributable to the drug were
                found. Modelling predicts a 98% reduction in infectious vector
                density by using an ivermectin formulation with a 12-week
                duration. CONCLUSIONS: These results indicate that relatively
                stable mosquitocidal plasma levels of ivermectin can be safely
                sustained in rabbits for up to six months using a silicone-based
                subcutaneous formulation. Modifying the formulation of
                ivermectin promises to be a suitable strategy for malaria vector
                control.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Screening for an ivermectin slow-release formulation suitable
                for malaria vector control