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Epigenetic Regulation of miR-212 Expression in Lung Cancer

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Many studies have shown that microRNA expression in cancer may be regulated by epigenetic events. Recently, we found that in lung cancer miR-212 was strongly down-regulated. However, mechanisms involved in the regulation of miR-212 expression are unknown. Therefore, we addressed this point by investigating the molecular mechanisms of miR-212 silencing in lung cancer. We identified histone modifications rather than DNA hypermethylation as epigenetic events that regulate miR-212 levels in NSCLC. Moreover, we found that miR-212 silencing in vivo is closely associated with the severity of the disease.

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Articles publicats en revistes (Ciències Fisiològiques)

# metadata.dc.title[].value
Epigenetic Regulation of miR-212 Expression in Lung Cancer