# name
Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells

# metadata.dc.description.abstract[].value
Background: iPSC (induced pluripotent stem cells) banks of iPSC lines with homozygous HLA (human leukocyte
antigen) haplotypes (haplobanks) are proposed as an affordable and off-the-shelf approach to allogeneic
transplantation of iPSC derived cell therapies. Cord blood banks offer an extensive source of HLA-typed cells
suitable for reprogramming to iPSC. Several initiatives worldwide have been undertaken to create national and
international iPSC haplobanks that match a significant part of a population.
Methods: To create an iPSC haplobank that serves the Spanish population (IPS-PANIA), we have searched the
Spanish Bone Marrow Donor Registry (REDMO) to identify the most frequently estimated haplotypes. From the top
ten donors identified, we estimated the population coverage using the criteria of zero mismatches in HLA-A, HLA-B,
and HLA-DRB1 with different stringencies: high resolution, low resolution, and beneficial mismatch.
Results: We have calculated that ten cord blood units from homozygous donors stored at the Spanish cord blood
banks can provide HLA-A, HLA-B, and HLA-DRB1 matching for 28.23% of the population.
Conclusion: We confirm the feasibility of using banked cord blood units to create an iPSC haplobank that will
cover a significant percentage of the Spanish and international population for future advanced therapy
replacement strategies.

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Stem Cell Research & Therapy, 2021, vol. 12

# metadata.dc.source[].value
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

# metadata.dc.title[].value
Evaluation of the Spanish population coverage of a prospective HLA haplobank of induced pluripotent stem cells