# name
Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory
                Biomarkers during Early and Chronic HIV Infection in Mozambican
                Adults

# metadata.dc.description.abstract[].value
During primary HIV infection (PHI), there is a striking cascade
                response of inflammatory cytokines and many cells of the immune
                system show altered frequencies and signs of extensive
                activation. These changes have been shown to have a relevant
                role in predicting disease progression; however, the challenges
                of identifying PHI have resulted in a lack of critical
                information about the dynamics of early pathogenic events. We
                studied soluble inflammatory biomarkers and changes in T-cell
                subsets in individuals at PHI (n = 40), chronic HIV infection
                (CHI, n = 56), and HIV-uninfected (n = 58) recruited at the
                Manhica District Hospital in Mozambique. Plasma levels of 49
                biomarkers were determined by Luminex and ELISA. T-cell
                immunophenotyping was performed by multicolor flow cytometry.
                Plasma HIV viremia, CD4, and CD8 T cell counts underwent rapid
                stabilization after PHI. However, several immunological
                parameters, including Th1-Th17 CD4 T cells and activation or
                exhaustion of CD8 T cells continued decreasing until more than 9
                months postinfection. Importantly, no sign of immunosenescence
                was observed over the first year of HIV infection. Levels of
                IP-10, MCP-1, BAFF, sCD14, tumor necrosis factor receptor-2, and
                TRAIL were significantly overexpressed at the first month of
                infection and underwent a prompt decrease in the subsequent
                months while, MIG and CD27 levels began to increase 1 month
                after infection and remained overexpressed for almost 1 year
                postinfection. Early levels of soluble biomarkers were
                significantly associated with subsequently exhausted CD4 T-cells
                or with CD8 T-cell activation. Despite rapid immune control of
                virus replication, the stabilization of the T-cell subsets
                occurs months after viremia and CD4 count plateau, suggesting
                persistent immune dysfunction and highlighting the potential
                benefit of early treatment initiation that could limit
                immunological damage.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.3389/fimmu.2017.01925

# metadata.dc.relation.ispartof[].value
Frontiers in Immunology, 2017, vol. 8, num. 1925

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Dynamics of CD4 and CD8 T-Cell Subsets and Inflammatory
                Biomarkers during Early and Chronic HIV Infection in Mozambican
                Adults