# name
Absence of hepatitis delta infection in a large rural HIV cohort
                in Tanzania

# metadata.dc.description.abstract[].value
OBJECTIVES: The epidemiological and clinical determinants of
                hepatitis delta virus (HDV) infection in Sub-Saharan Africa are
                ill-defined. The prevalence of HDV infection was determined in
                HIV/hepatitis B virus (HBV) co-infected individuals in rural
                Tanzania. METHODS: All hepatitis B virus (HBV)-infected adults
                under active follow-up in the Kilombero and Ulanga
                Antiretroviral Cohort (KIULARCO) were screened for anti-HDV
                antibodies. For positive samples, a second serological test and
                nucleic acid amplification were performed. Demographic and
                clinical characteristics at initiation of antiretroviral therapy
                (ART) were compared between anti-HDV-negative and positive
                patients. RESULTS: Among 222 HIV/HBV co-infected patients on
                ART, 219 (98.6%) had a stored serum sample available and were
                included in the study. Median age was 37 years, 55% were female,
                46% had World Health Organization stage III/IV HIV disease, and
                the median CD4 count was 179 cells/mul. The prevalence of
                anti-HDV positivity was 5.0% (95% confidence interval 2.8-8.9%).
                There was no significant predictor of anti-HDV positivity. HDV
                could not be amplified in any of the anti-HDV-positive patients
                and the second serological test was negative in all of them.
                CONCLUSIONS: No confirmed case of HDV infection was found among
                over 200 HIV/HBV co-infected patients in Tanzania. As
                false-positive serology results are common, screening results
                should be confirmed with a second test.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1016/j.ijid.2016.03.011

# metadata.dc.relation.ispartof[].value
International Journal of Infectious Diseases, 2016, vol. 46, p. 8-10

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Absence of hepatitis delta infection in a large rural HIV cohort
                in Tanzania