# name
Combating virulence of Gramnegative bacilli by OmpA inhibition

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Preventing the adhesion of pathogens to host cells provides an innovative approach to tackling multidrug-resistant bacteria. In this regard, the identification of outer membrane protein A (OmpA) as a key bacterial virulence factor has been a major breakthrough. The use of virtual screening helped us to identify a cyclic hexapeptide AOA-2 that inhibits the adhesion of Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia coli to host cells and the formation of biofilm, thereby preventing the development of infection in vitro and in a murine sepsis peritoneal model. Inhibition of OmpA offers a strategy as monotherapy to address the urgent need for treatments for infections caused by Gram-negative bacilli.

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Scientific Reports, 2017, vol. 7, num. 14683

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cc-by (c) Vila Farres, Xavier et al., 2017

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Articles publicats en revistes (Química Inorgànica i Orgànica)

# metadata.dc.title[].value
Combating virulence of Gramnegative bacilli by OmpA inhibition