# name
Ambient Air Pollution and Cancer Mortality in the Cancer
                Prevention Study II

# metadata.dc.description.abstract[].value
BACKGROUND: The International Agency for Research on Cancer
                classified both outdoor air pollution and airborne particulate
                matter as carcinogenic to humans (Group 1) for lung cancer.
                There may be associations with cancer at other sites; however,
                the epidemiological evidence is limited. OBJECTIVE: The aim of
                this study was to clarify whether ambient air pollution is
                associated with specific types of cancer other than lung cancer
                by examining associations of ambient air pollution with nonlung
                cancer death in the Cancer Prevention Study II (CPS-II).
                METHODS: Analysis included 623,048 CPS-II participants who were
                followed for 22 y (1982-2004). Modeled estimates of particulate
                matter with aerodynamic diameter <2.5microm (PM2.5)
                (1999-2004), nitrogen dioxide (NO2) (2006), and ozone (O3)
                (2002-2004) concentrations were linked to the participant
                residence at enrollment. Cox proportional hazards models were
                used to estimate associations per each fifth percentile-mean
                increment with cancer mortality at 29 anatomic sites, adjusted
                for individual and ecological covariates. RESULTS: We observed
                43,320 nonlung cancer deaths. PM2.5 was significantly positively
                associated with death from cancers of the kidney {adjusted
                hazard ratio (HR) per 4.4 mug/m3=1.14 [95% confidence interval
                (CI): 1.03, 1.27]} and bladder [HR=1.13 (95% CI: 1.03, 1.23)].
                NO2 was positively associated with colorectal cancer mortality
                [HR per 6.5 ppb=1.06 (95% CI: 1.02, 1.10). The results were
                similar in two-pollutant models including PM2.5 and NO2 and in
                three-pollutant models with O3. We observed no statistically
                significant positive associations with death from other types of
                cancer based on results from adjusted models. CONCLUSIONS: The
                results from this large prospective study suggest that ambient
                air pollution was not associated with death from most nonlung
                cancers, but associations with kidney, bladder, and colorectal
                cancer death warrant further investigation.
                https://doi.org/10.1289/EHP1249.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1289/EHP1249

# metadata.dc.relation.ispartof[].value
Environmental Health Perspectives, 2017, vol. 125, num. 8, p.
                087013

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Ambient Air Pollution and Cancer Mortality in the Cancer
                Prevention Study II