# name
Combating virulence of Gram-negative bacilli by OmpA inhibition

# metadata.dc.description.abstract[].value
Preventing the adhesion of pathogens to host cells provides an
                innovative approach to tackling multidrug-resistant bacteria. In
                this regard, the identification of outer membrane protein A
                (OmpA) as a key bacterial virulence factor has been a major
                breakthrough. The use of virtual screening helped us to identify
                a cyclic hexapeptide AOA-2 that inhibits the adhesion of
                Acinetobacter baumannii, Pseudomonas aeruginosa and Escherichia
                coli to host cells and the formation of biofilm, thereby
                preventing the development of infection in vitro and in a murine
                sepsis peritoneal model. Inhibition of OmpA offers a strategy as
                monotherapy to address the urgent need for treatments for
                infections caused by Gram-negative bacilli.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Combating virulence of Gram-negative bacilli by OmpA inhibition