# name
The machinery underlying malaria parasite virulence is conserved
                between rodent and human malaria parasites

# metadata.dc.description.abstract[].value
Sequestration of red blood cells infected with the human malaria
                parasite Plasmodium falciparum in organs such as the brain is
                considered important for pathogenicity. A similar phenomenon has
                been observed in mouse models of malaria, using the rodent
                parasite Plasmodium berghei, but it is unclear whether the P.
                falciparum proteins known to be involved in this process are
                conserved in the rodent parasite. Here we identify the P.
                berghei orthologues of two such key factors of P. falciparum,
                SBP1 and MAHRP1. Red blood cells infected with P. berghei
                parasites lacking SBP1 or MAHRP1a fail to bind the endothelial
                receptor CD36 and show reduced sequestration and virulence in
                mice. Complementation of the mutant P. berghei parasites with
                the respective P. falciparum SBP1 and MAHRP1 orthologues
                restores sequestration and virulence. These findings reveal
                evolutionary conservation of the machinery underlying
                sequestration of divergent malaria parasites and support the
                notion that the P. berghei rodent model is an adequate tool for
                research on malaria virulence.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1038/ncomms11659

# metadata.dc.relation.ispartof[].value
Nature Communications, 2016, vol. 7, num. 11659

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
The machinery underlying malaria parasite virulence is conserved
                between rodent and human malaria parasites