# name
The brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids

# metadata.dc.description.abstract[].value
Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glau-cescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crys-tallographic data for four galanthamine-type com-pounds revealed significant differences in the orientation of theN-methyl group, which are shown to be related to AChE inhibition.

# metadata.dc.rights[].value
(c) Springer Science + Business Media, 2016

# metadata.dc.source[].value
Articles publicats en revistes (Mineralogia, Petrologia i Geologia Aplicada)

# metadata.dc.title[].value
The brazilian Amaryllidaceae as a source of acetylcholinesterase inhibitory alkaloids