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A general methodology for the enantioselective synthesis of 1-substituted tetrahydroisoquinoline alkaloids

# metadata.dc.description.abstract[].value
Starting from tricyclic lactam 2 , which is easily accessible by cyclocondensation of δ‐oxoester 1 with (R )‐phenylglycinol, a three‐step synthetic route to enantiopure 1‐substituted tetrahydroisoquinolines, including 1‐alkyl‐, 1‐aryl‐, and 1‐benzyltetrahydroisoquinoline alkaloids, as well as the tricyclic alkaloid (-)‐crispine A, has been developed. The key step is a stereoselective α‐amidoalkylation reaction using the appropriate Grignard reagent.

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European Journal of Organic Chemistry, 2010, vol. 2010, num. 21, p. 4017-4026

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Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
A general methodology for the enantioselective synthesis of 1-substituted tetrahydroisoquinoline alkaloids