# name
Frequency of driver oncogenic alterations in NSCLC and estimated indoor radon exposure in Europe (RADON EUROPE study).

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Background: Geographical variations in the frequency of oncogenic driver alterations in non-small cell lung cancer (NSCLC) are observed worldwide, likely influenced by genetic and environmental factors. Radon, a leading cause of lung cancer in nonsmokers, may influence NSCLC's molecular profile.

Objectives: This study aims to explore the potential correlation between estimated indoor radon concentrations and the frequency of driver alterations in NSCLC across Europe.

Design: Ecological study of European countries with available data on indoor radon exposure (estimated mean levels and the proportion (%) of dwellings with concentrations >200 and >400 Bq/m3), and frequency of NSCLC actionable genomic alterations (EGFR, ALK) from PubMed articles and meeting abstracts with sample size >100 patients.

Methods: We retrospectively analyzed NSCLC molecular data and radon exposure levels from European countries. Radon data, including the mean and proportion (%) of dwellings with concentrations >200 and >400 Bq/m3, were sourced from the European Commission Report 2005. NSCLC molecular alteration frequency (EGFR, ALK) was extracted from PubMed articles with sample sizes >100 patients. The correlation between molecular alteration frequencies and country-specific radon data were assessed.

Results: Data on radon exposure and EGFR/ALK frequency were available for 21 European countries. Five countries had mean radon levels >100 Bq/m3, and eight countries had ⩾3% of dwellings with concentrations >400 Bq/m3. The median frequency of EGFR mutations and ALK fusions was 11.3% (range 7%-18.1%) and 4.1% (range 3.4%-12%), respectively. A positive correlation was found between estimated ALK-fusion frequency and the percentage of dwellings with >400 Bq/m3 (r = 0.72, p = 0.001). No correlation was found between EGFR mutation frequency and radon exposure.

Conclusion: We found a positive correlation between estimated ALK fusion frequency in NSCLC and the proportion of dwellings exceeding 400 Bq/m3 radon exposure in 21 European countries. Further research is needed to explore the potential influence of radon and other environmental factors on NSCLC with driver alterations.

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Therapeutic Advances In Medical Oncology, 2025, vol. 17

# metadata.dc.rights[].value
cc-by-nc (c) García Pardo, Miguel et al., 2025

# metadata.dc.source[].value
Articles publicats en revistes (Medicina)

# metadata.dc.title[].value
Frequency of driver oncogenic alterations in NSCLC and estimated indoor radon exposure in Europe (RADON EUROPE study).