# metadata.dc.description.abstract[].value
Solvent effects in the L-tryptophan-catalyzed Mannich reaction between hydroxyacetone and glyoxylate imines have been examined. The use of a DMSO/1-butanol (4:1 v/v) mixture as solvent at rt provided the expected Mannich adducts in good yields, high anti-diastereoselectivity (up to 10.3:1 anti/syn ratio) and excellent enantioselectivities (up to >99.9% ee for the anti isomer)

# metadata.dc.relation.ispartof[].value
Asymmetric Catalysis, 2015, vol. 2, num. 1, p. 7-16

# metadata.dc.rights[].value
cc by-nc-nd (c) Valero González, Guillem et al., 2015

# metadata.dc.source[].value
Articles publicats en revistes (Química Inorgànica i Orgànica)