# metadata.dc.description.abstract[].value
A novel method to synthesize cyclic oligonucleotides (5- to 26-mer) using the thiol-maleimide reaction is described. The target molecules were obtained after subsequent removal of thiol and maleimide protecting groups from 5′-maleimido-3′-thiol-derivatized linear precursors. Retro-Diels-Alder conditions deprotecting the maleimide simultaneously promoted cyclization cleanly and in high yield.

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a: http://dx.doi.org/ 10.1039/C2CC35357A

# metadata.dc.source[].value
Articles publicats en revistes (Química Inorgànica i Orgànica)