# name
Optimization of an obtaining nanotubes process

# metadata.dc.description[].value
Treballs Finals de Grau d'Enginyeria Biomèdica. Facultat de Medicina i Ciències de la Salut. Universitat de Barcelona. Curs: 2020-2021. Director: Javier Fernández González. Tutor: Raisha García

# metadata.dc.description.abstract[].value
Because of the aging of the population and the increase medical interventions with prothesis, the use of
metallic implants is increasing exponentially rising the need to improve their lifespan and biocompatibility.
So that, it is important to improve how the material interact with the tissues of the body. That is the reason
why, this project has aimed at making surface modifications of titanium implants to increase their
bioactivity.
Specifically, this study has been focused on making surface modifications using an electrochemical
anodization process of a particular titanium alloy, Ti-6Al-7Nb, to generate nanotubes. Through the
electrochemical anodization process, a titanium dioxide (TiO2) layer is generated. This oxide layer
provides the surface with a high corrosion resistance that protects and prevents the release of ions from
the implant to the body. Also, this TiO2 layer is a bioactive ceramic material which will favor cell adhesion
and proliferation. Therefore, this project has consisted of three steps: optimize the conditions to create
nanotubes on an industrial level, characterize the coatings made through imaging with different
microscopic techniques and finally validate the sample bioactivity by cellular viability tests.
Last but not least, it is important to note the methodology behind this degree thesis. First the background
of titanium and its alloys as a biomaterial is explained, as well as the evolution of implants and current
techniques available to improve the bioactivity of surfaces. In addition, a market study has been carried
out and both the technical and economic feasibility of the project have been studied. Finally, the current
regulations on medical devices have been considered. To sum up, it has been possible to establish an
overview of the aspects necessary to carry out modifications of surfaces of medical implants.

# metadata.dc.rights[].value
cc-by-nc-nd (c) Mirón Barbosa, Eva, 2021

# metadata.dc.source[].value
Treballs Finals de Grau (TFG) - Enginyeria Biomèdica

# metadata.dc.title[].value
Optimization of an obtaining nanotubes process