# name
IgM and IgG against Plasmodium falciparum lysate as surrogates
                of malaria exposure and protection during pregnancy

# metadata.dc.description.abstract[].value
BACKGROUND: Difficulties to disentangle the protective versus
                exposure role of anti-malarial antibodies hamper the
                identification of clinically-relevant immune targets. Here,
                factors affecting maternal IgG and IgMs against Plasmodium
                falciparum antigens, as well as their relationship with parasite
                infection and clinical outcomes, were assessed in mothers and
                their children. Antibody responses among 207 Mozambican pregnant
                women at delivery against MSP119, EBA175, AMA1, DBLalpha and
                parasite lysate (3D7, R29 and E8B parasite lines), as well as
                the surface of infected erythrocytes, were assessed by
                enzyme-linked immunosorbent assay and flow cytometry. The
                relationship between antibody levels, maternal infection and
                clinical outcomes was assessed by multivariate regression
                analysis. RESULTS: Placental infection was associated with an
                increase in maternal levels of IgGs and IgMs against a broad
                range of parasite antigens. The multivariate analysis including
                IgGs and IgMs showed that the newborn weight increased with
                increasing IgG levels against a parasite lysate, whereas the
                opposite association was found with IgMs. IgGs are markers of
                protection against poor pregnancy outcomes and IgMs of parasite
                exposure. CONCLUSIONS: Adjusting the analysis for the
                simultaneous effect of IgMs and IgGs can contribute to account
                for heterogeneous exposure to P. falciparum when assessing
                immune responses effective against malaria in pregnancy.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
IgM and IgG against Plasmodium falciparum lysate as surrogates
                of malaria exposure and protection during pregnancy