# name
Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes

# metadata.dc.description.abstract[].value
Plasmodium vivax malaria is a neglected disease,
                particularly during pregnancy. Severe vivax malaria is
                associated with inflammatory responses but in pregnancy immune
                alterations make it uncertain as to what cytokine signatures
                predominate, and how the type and quantity of blood immune
                mediators influence delivery outcomes. We measured the plasma
                concentrations of a set of thirty-one biomarkers, comprising
                cytokines, chemokines and growth factors, in 987 plasma samples
                from a cohort of 572 pregnant women from five malaria-endemic
                tropical countries and related these concentrations to delivery
                outcomes (birth weight and hemoglobin levels) and malaria
                infection. Samples were collected at recruitment (first
                antenatal visit) and at delivery (periphery, cord and placenta).
                At recruitment, we found that P. vivax-infected pregnant women
                had higher plasma concentrations of proinflammatory (IL-6,
                IL-1\xCE\xB2, CCL4, CCL2, CXCL10) and TH1-related cytokines
                (mainly IL-12) than uninfected women. This biomarker signature
                was essentially lost at delivery and was not associated with
                birth weight nor hemoglobin levels. Antiinflammatory cytokines
                (IL-10) were positively associated with infection and poor
                delivery outcomes. CCL11 was the only biomarker to show a
                negative association with P. vivax infection and its
                concentration at recruitment was positively associated with
                hemoglobin levels at delivery. Birth weight was negatively
                associated with peripheral IL-4 levels at delivery. Our
                multi-biomarker multicenter study is the first comprehensive one
                to characterize the immunological signature of P. vivax
                infection in pregnancy thus far. In conclusion, data show that
                while TH1 and pro-inflammatory responses are dominant during P.
                vivax infection in pregnancy, antiinflammatory cytokines may
                compensate excessive inflammation avoiding poor delivery
                outcomes, and skewness toward a TH2 response may trigger worse
                delivery outcomes. CCL11, a chemokine largely neglected in the
                field of malaria, emerges as an important marker of exposure or
                mediator in this condition.

# metadata.dc.relation.ispartof[].value
PLoS Neglected Tropical Diseases, 2020, vol. 14, num. 5, p. e0008155

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Cytokine signatures of Plasmodium vivax infection during pregnancy and delivery outcomes