# name
Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis

# metadata.dc.description.abstract[].value
BACKGROUND: Women of reproductive age can be exposed to
                endocrine-disrupting chemicals (EDCs) at work and exposure to
                EDCs in pregnancy may affect fetal growth. OBJECTIVES: We
                assessed whether maternal occupational exposure to EDCs during
                pregnancy as classified by application of a job exposure matrix
                was associated with birth weight, term low birth weight (LBW),
                length of gestation, and preterm delivery. METHODS: Using
                individual participant data from 133,957 mother-child pairs in
                13 European cohorts spanning births from 1994 to 2011, we linked
                maternal job titles with exposure to 10 EDC groups as assessed
                through a job exposure matrix. For each group, we combined the
                two levels of exposure categories (possible and probable) and
                compared birth outcomes with the unexposed group (exposure
                unlikely). We performed meta-analyses of cohort-specific
                estimates. RESULTS: Eleven percent of pregnant women were
                classified as exposed to EDCs at work during pregnancy based on
                job title. Classification of exposure to one or more EDC group
                was associated with an increased risk of term LBW (OR 1.25,
                95%CI 1.04, 1.49), as were most specific EDC groups; this
                association was consistent across cohorts. Further, the risk
                increased with increasing number of EDC groups (OR 2.11 95%CI
                1.10, 4.06 for exposure to 4 or more EDC groups). There were few
                associations (p < 0.05) with the other outcomes; women
                holding job titles classified as exposed to bisphenol A or
                brominated flame retardants were at higher risk for longer
                length of gestation. CONCLUSION: Results from our large
                population-based birth cohort design indicate that employment
                during pregnancy in occupations classified as possibly or
                probably exposed to EDCs was associated with an increased risk
                of term LBW.

# metadata.dc.publisher[].value
National Institute of Environmental Health Sciences (NIEHS)

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1289/EHP208

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Occupational Exposure to Endocrine-Disrupting Chemicals and Birth Weight and Length of Gestation: A European Meta-Analysis