# name
Effects of exposure to water disinfection by-products in a
                swimming pool: A metabolome-wide association study

# metadata.dc.description.abstract[].value
BACKGROUND: Exposure to disinfection by-products (DBPs) in
                drinking water and chlorinated swimming pools are associated
                with adverse health outcomes, but biological mechanisms remain
                poorly understood. OBJECTIVES: Evaluate short-term changes in
                metabolic profiles in response to DBP exposure while swimming in
                a chlorinated pool. MATERIALS AND METHODS: The PISCINA-II study
                (EXPOsOMICS project) includes 60 volunteers swimming 40min in an
                indoor pool. Levels of most common DBPs were measured in water
                and in exhaled breath before and after swimming. Blood samples,
                collected before and 2h after swimming, were used for metabolic
                profiling by liquid-chromatography coupled to high-resolution
                mass-spectrometry. Metabolome-wide association between DBP
                exposures and each metabolic feature was evaluated using
                multivariate normal (MVN) models. Sensitivity analyses and
                compound annotation were conducted. RESULTS: Exposure levels of
                all DBPs in exhaled breath were higher after the experiment. A
                total of 6,471 metabolic features were detected and 293 features
                were associated with at least one DBP in exhaled breath
                following Bonferroni correction. A total of 333 metabolic
                features were associated to at least one DBP measured in water
                or urine. Uptake of DBPs and physical activity were strongly
                correlated and mutual adjustment reduced the number of
                statistically significant associations. From the 293 features,
                20 could be identified corresponding to 13 metabolites including
                compounds in the tryptophan metabolism pathway. CONCLUSION: Our
                study identified numerous molecular changes following a swim in
                a chlorinated pool. While we could not explicitly evaluate which
                experiment-related factors induced these associations, molecular
                characterization highlighted metabolic features associated with
                exposure changes during swimming.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1016/j.envint.2017.11.017

# metadata.dc.relation.ispartof[].value
Environment International, 2017, vol. 111, num. , p. 60-70

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Effects of exposure to water disinfection by-products in a
                swimming pool: A metabolome-wide association study