# name
Sphingolipid metabolism products: potential new players in the pathogenesis of bortezomib-induced neuropathic pain

# metadata.dc.description.abstract[].value
Chemotherapy-induced peripheral neurotoxicity (CIPN) is one of the major dose-limiting adverse events of widely used drugs in both the oncologic and hematologic setting (1). Among its cardinal symptoms, neuropathic pain is frequently present (2). In particular, the incidence of bortezomib-induced peripheral neurotoxicity (BIPN) and neuropathic pain ranges from 14–45% and 5–39%, respectively, in myeloma multiple patients. BIPN is more frequently developed in pretreated patients, compared to those being chemotherapy-naïve (3,4), and this difference mostly accounts for the wide variability in the observed incidence rates. Bortezomib is the first proteasome inhibitor introduced in clinical practice. The mechanisms underlying the pathogenesis of peripheral neurotoxicity in bortezomib- treated patients are, yet, not fully elucidated (3,4).

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Annals of Translational Medicine, 2018, vol. 6

# metadata.dc.rights[].value
cc by-nc-nd (c) Annals of Translational Medicine, 2018

# metadata.dc.source[].value
Articles publicats en revistes (Institut d'lnvestigació Biomèdica de Bellvitge (IDIBELL))

# metadata.dc.title[].value
Sphingolipid metabolism products: potential new players in the pathogenesis of bortezomib-induced neuropathic pain