# name
Poor tuberculosis treatment outcomes in Southern Mozambique
                (2011-2012)

# metadata.dc.description.abstract[].value
BACKGROUND: In Mozambique, there is limited data regarding the
                monitoring of Tuberculosis (TB) treatment results and
                determinants of adverse outcomes under routine surveillance
                conditions. The objectives of this study were to evaluate
                treatment outcomes among TB patients, analyze factors associated
                with a fatal outcome and determine the proportion of deaths
                attributable to TB in the district of Manhica, Southern
                Mozambique. METHODS: This is a retrospective observational study
                based on TB patients diagnosed in the period 2011-2012. We used
                three different data sources: a) TB related variables collected
                by the National TB Control Program in the district of Manhica
                for all TB cases starting treatment in the period 2011-2012. b)
                Population estimates for the district were obtained through the
                Mozambican National Statistics Institute. c) Deaths and other
                relevant demographic variables were collected from the Health
                and Demographic Surveillance System at Manhica Health Research
                Center. WHO guidelines were used to define TB cases and
                treatment outcomes. RESULTS: Of the 1957 cases starting TB
                treatment in the period 2011-2012, 294 patients (15.1 %) died
                during anti-tuberculous treatment. Ten per cent of patients
                defaulted treatment. The proportion of patients considered to
                have treatment failure was 1.1 %. HIV infection (OR 2.73; 95 %
                CI: 1.70-4.38), being female (OR: 1.39; 95 % CI: 1.31-1.91) and
                lack of laboratory confirmation (OR 1.51; 95 % CI: 1.10-2.08)
                were associated with dying during the course of TB treatment (p
                value <0.05). The contribution of TB to the overall death
                burden of the district for natural reasons was 6.5 % (95 % CI:
                5.5-7.6), higher for males than for females (7.8 %; 95 % CI:
                6.1-9.5 versus 5.4 %; 95 % CI: 4.1-6.8 respectively). The age
                group within which TB was responsible for the highest proportion
                of deaths was 30-34 among males and 20-24 among females (20 % of
                all deaths in both cases). CONCLUSION: This study shows a very
                high proportion of fatal outcomes among TB cases starting
                treatment. There is a high contribution of TB to the overall
                causes of mortality. These results call for action in order to
                improve TB (and TB/HIV) management and thus treatment outcomes
                of TB patients.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1186/s12879-016-1534-y

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Poor tuberculosis treatment outcomes in Southern Mozambique
                (2011-2012)