# name
Infant Group B Streptococcal Disease Incidence and Serotypes
                Worldwide: Systematic Review and Meta-analyses

# metadata.dc.description.abstract[].value
Background: Group B Streptococcus (GBS) remains a leading cause
                of neonatal sepsis in high-income contexts, despite declines due
                to intrapartum antibiotic prophylaxis (IAP). Recent evidence
                suggests higher incidence in Africa, where IAP is rare. We
                investigated the global incidence of infant invasive GBS disease
                and the associated serotypes, updating previous estimates.
                Methods: We conducted systematic literature reviews
                (PubMed/Medline, Embase, Latin American and Caribbean Health
                Sciences Literature [LILACS], World Health Organization Library
                Information System [WHOLIS], and Scopus) and sought unpublished
                data regarding invasive GBS disease in infants aged 0-89 days.
                We conducted random-effects meta-analyses of incidence, case
                fatality risk (CFR), and serotype prevalence. Results: We
                identified 135 studies with data on incidence (n = 90), CFR (n =
                64), or serotype (n = 45). The pooled incidence of invasive GBS
                disease in infants was 0.49 per 1000 live births (95% confidence
                interval [CI], .43-.56), and was highest in Africa (1.12) and
                lowest in Asia (0.30). Early-onset disease incidence was 0.41
                (95% CI, .36-.47); late-onset disease incidence was 0.26 (95%
                CI, .21-.30). CFR was 8.4% (95% CI, 6.6%-10.2%). Serotype III
                (61.5%) dominated, with 97% of cases caused by serotypes Ia, Ib,
                II, III, and V. Conclusions: The incidence of infant GBS disease
                remains high in some regions, particularly Africa. We likely
                underestimated incidence in some contexts, due to limitations in
                case ascertainment and specimen collection and processing.
                Burden in Asia requires further investigation.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
               https://doi.org/10.1093/cid/cix656

# metadata.dc.relation.ispartof[].value
Clinical Infectious Diseases, 2017, vol. 65, num. suppl_2, p.
                S160-S172

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Infant Group B Streptococcal Disease Incidence and Serotypes
                Worldwide: Systematic Review and Meta-analyses