# name
The complex relationship of exposure to new Plasmodium
                infections and incidence of clinical malaria in Papua New Guinea

# metadata.dc.description.abstract[].value
The molecular force of blood-stage infection (molFOB) is a
                quantitative surrogate metric for malaria transmission at
                population level and for exposure at individual level.
                Relationships between molFOB, parasite prevalence and clinical
                incidence were assessed in a treatment-to-reinfection cohort,
                where P.vivax (Pv) hypnozoites were eliminated in half the
                children by primaquine (PQ). Discounting relapses, children
                acquired equal numbers of new P. falciparum (Pf) and Pv
                blood-stage infections/year (Pf-molFOB = 0-18, Pv-molFOB = 0-23)
                resulting in comparable spatial and temporal patterns in
                incidence and prevalence of infections. Including relapses,
                Pv-molFOB increased >3 fold (relative to PQ-treated children)
                showing greater heterogeneity at individual (Pv-molFOB = 0-36)
                and village levels. Pf- and Pv-molFOB were strongly associated
                with clinical episode risk. Yearly Pf clinical incidence rate
                (IR = 0.28) was higher than for Pv (IR = 0.12) despite lower
                Pf-molFOB. These relationships between molFOB, clinical
                incidence and parasite prevalence reveal a comparable decline in
                Pf and Pv transmission that is normally hidden by the high
                burden of Pv relapses. CLINICAL TRIAL REGISTRATION:
                ClinicalTrials.gov NCT02143934.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.7554/eLife.23708

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
The complex relationship of exposure to new Plasmodium
                infections and incidence of clinical malaria in Papua New Guinea