# name
IP-10 Kinetics in the First Week of Therapy are Strongly
                Associated with Bacteriological Confirmation of Tuberculosis
                Diagnosis in HIV-Infected Patients

# metadata.dc.description.abstract[].value
Simple effective tools to monitor the long treatment of
                tuberculosis (TB) are lacking. Easily measured host derived
                biomarkers have been identified but need to be validated in
                larger studies and different population groups. Here we
                investigate the early response in IP-10 levels (between day 0
                and day 7 of TB therapy) to identify bacteriological status at
                diagnosis among 127 HIV-infected patients starting TB treatment.
                All participants were then classified as responding or not
                responding to treatment blindly using a previously described
                IP-10 kinetic algorithm. There were 77 bacteriologically
                confirmed cases and 41 Xpert MTB/RIF(R) and culture negative
                cases. Most participants had a measurable decline in IP-10
                during the first 7 days of therapy. Bacteriologically confirmed
                cases were more likely to have high IP-10 levels at D0 and had a
                steeper decline than clinically diagnosed cases (mean decline
                difference 2231 pg/dl, 95% CI: 897-3566, p = 0.0013).
                Bacteriologically confirmed cases were more likely to have a
                measurable decline in IP-10 at day 7 than clinically diagnosed
                cases (48/77 (62.3%) vs 13/41 (31.7%), p < 0.001). This study
                confirms the association between a decrease in IP-10 levels
                during the first week of treatment and a bacteriological
                confirmation at diagnosis in a large cohort of HIV positive
                patients.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
IP-10 Kinetics in the First Week of Therapy are Strongly
                Associated with Bacteriological Confirmation of Tuberculosis
                Diagnosis in HIV-Infected Patients