# name
Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein in Pregnant Women Are Associated with Higher Birth Weight in a Multicenter Study

# metadata.dc.description.abstract[].value
A vaccine to eliminate malaria would need a multi-stage and
                multi-species composition to achieve robust protection, but the
                lack of knowledge about antigen targets and mechanisms of
                protection precludes the development of fully efficacious
                malaria vaccines, especially for Plasmodium vivax (Pv). Pregnant
                women constitute a risk population who would greatly benefit
                from a vaccine preventing the adverse events of Plasmodium
                infection during gestation. We hypothesized that functional
                immune responses against putative targets of naturally acquired
                immunity to malaria and vaccine candidates will be associated
                with protection against malaria infection and/or poor outcomes
                during pregnancy. We measured (i) IgG responses to a large panel
                of Pv and Plasmodium falciparum (Pf) antigens, (ii) the capacity
                of anti-Pv ligand Duffy binding protein (PvDBP) antibodies to
                inhibit binding to Duffy antigen, and (iii) cellular immune
                responses to two Pv antigens, in a subset of 1,056 pregnant
                women from Brazil, Colombia, Guatemala, India, and Papua New
                Guinea (PNG). There were significant intraspecies and
                interspecies correlations for most antibody responses (e.g.,
                PfMSP119 versus PfAMA1, Spearman's rho = 0.81). Women from PNG
                and Colombia had the highest levels of IgG overall.
                Submicroscopic infections seemed sufficient to boost antibody
                responses in Guatemala but not antigen-specific cellular
                responses in PNG. Brazil had the highest percentage of Duffy
                binding inhibition (p-values versus Colombia: 0.040; Guatemala:
                0.047; India: 0.003, and PNG: 0.153) despite having low
                anti-PvDBP IgG levels. Almost all antibodies had a positive
                association with present infection, and coinfection with the
                other species increased this association. Anti-PvDBP,
                anti-PfMSP1, and anti-PfAMA1 IgG levels at recruitment were
                positively associated with infection at delivery (p-values:
                0.010, 0.003, and 0.023, respectively), suggesting that they are
                markers of malaria exposure. Peripheral blood mononuclear cells
                from Pv-infected women presented fewer CD8+IFN-gamma+ T cells
                and secreted more G-CSF and IL-4 independently of the stimulus
                used in vitro. Functional anti-PvDBP levels at recruitment had a
                positive association with birth weight (difference per doubling
                antibody levels: 45 g, p-value: 0.046). Thus, naturally acquired
                binding-inhibitory antibodies to PvDBP might confer protection
                against poor outcomes of Pv malaria in pregnancy.

# metadata.dc.relation.ispartof[].value
Frontiers in Immunology, 2017, vol. 8, num. 163

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Naturally Acquired Binding-Inhibitory Antibodies to Plasmodium vivax Duffy Binding Protein in Pregnant Women Are Associated with Higher Birth Weight in a Multicenter Study