# name
The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice

# metadata.dc.description.abstract[].value
Scope: The rosehip (Rosa canina) is a perennial shrub with a reddish
pseudofruit that has demonstrated antidiabetic, antiatherosclerotic, and
antiobesogenic effects in rodent models but there is low information about
the molecular mechanisms underlying these effects on the onset and
progression of diet-induced obesity.
Methods and results: Four-week-old C57BL/6J male mice are subjected to a
high-fat diet (HFD)-supplemented or not with R. canina flesh for 18 weeks.
The results indicated that the R. canina flesh exerts a preventive effect on
HFD-induced obesity with a significant reduction in body-weight gain and an
improvement of hyperglycemia and insulin resistance caused by a HFD. At
the tissue level, subcutaneous white adipose tissue exhibits a higher number
of smaller adipocytes, with decreased lipogenesis. On its side, the liver shows
a significant decrease in lipid droplet content and in the expression of genes
related to lipogenesis, fatty acid oxidation, and glucose metabolism. Finally,
the data suggest that most of these effects agree with the presence of a
putative Perosxisome proliferator-activated receptor gamma (PPAR  )
antagonist in the R. canina flesh.
Conclusions: R. canina flesh dietary supplementation slows down the
steatotic effect of a HFD at least in part through the regulation of the
transcriptional activity of PPAR  .

# metadata.dc.relation.ispartof[].value
Molecular Nutrition & Food Research, 2024, vol. 68, num.5, p. 2300539

# metadata.dc.rights[].value
cc-by (c) Sanz Lamora, Héctor et al., 2024

# metadata.dc.source[].value
Articles publicats en revistes (Nutrició, Ciències de l'Alimentació i Gastronomia)

# metadata.dc.title[].value
The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High-Fat Diet-Fed Mice