# name
Targeting cattle for malaria elimination: marked reduction of
                Anopheles arabiensis survival for over six months using a
                slow-release ivermectin implant formulation

# metadata.dc.description.abstract[].value
BACKGROUND: Mosquitoes that feed on animals can survive and
                mediate residual transmission of malaria even after most humans
                have been protected with insecticidal bednets or indoor residual
                sprays. Ivermectin is a widely-used drug for treating parasites
                of humans and animals that is also insecticidal, killing
                mosquitoes that feed on treated subjects. Mass administration of
                ivermectin to livestock could be particularly useful for
                tackling residual malaria transmission by zoophagic vectors that
                evade human-centred approaches. Ivermectin comes from a
                different chemical class to active ingredients currently used to
                treat bednets or spray houses, so it also has potential for
                mitigating against emergence of insecticide resistance. However,
                the duration of insecticidal activity obtained with ivermectin
                is critical to its effectiveness and affordability. RESULTS: A
                slow-release formulation for ivermectin was implanted into
                cattle, causing 40 weeks of increased mortality among Anopheles
                arabiensis that fed on them. For this zoophagic vector of
                residual malaria transmission across much of Africa, the
                proportion surviving three days after feeding (typical mean
                duration of a gonotrophic cycle in field populations) was
                approximately halved for 25 weeks. CONCLUSIONS: This implantable
                ivermectin formulation delivers stable and sustained
                insecticidal activity for approximately 6 months. Residual
                malaria transmission by zoophagic vectors could be suppressed by
                targeting livestock with this long-lasting formulation, which
                would be impractical or unacceptable for mass treatment of human
                populations.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1186/s13071-018-2872-y

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Targeting cattle for malaria elimination: marked reduction of
                Anopheles arabiensis survival for over six months using a
                slow-release ivermectin implant formulation