# name
Strengthening the Bolivian pharmacovigilance system: New
surveillance strategies to improve care for Chagas disease and
tuberculosis.

# metadata.dc.description.abstract[].value
"Chagas disease (CD) and tuberculosis (TB) are important
health problems in Bolivia. Current treatments for both
 infections require a long period of time, and adverse drug
reactions (ADRs) are frequent. This study aims to strengthen the
 Bolivian pharmacovigilance system, focusing on CD and TB. A
 situation analysis of pharmacovigilance in the Department of
 Cochabamba was performed. The use of a new local case report
                form (CRF) was implemented, together with the CRF established by the Unidad de Medicamentos y Tecnolog\xC3\xADa en Salud
                (UNIMED), in several healthcare centers. Training and follow-up
                on drug safety monitoring and ADR reporting was provided to all
                health professionals involved in CD and TB treatment. A
                comparative analysis of the reported ADRs using the CRF provided
                by UNIMED, the new CRF proposal, and medical records, was also performed. Our results showed that out of all patients starting
                treatment for CD, 37.9% suffered ADRs according to the medical
                records, and 25.3% of them were classified as moderate/severe
                (MS). Only 47.4% of MS ADRs were reported to UNIMED. Regarding
                TB treatment, 9.9% of all patients suffered ADRs, 44% of them
                were classified as MS, and 75% of MS ADRs were reported to
                UNIMED. These findings show that the reinforcement of the
                Bolivian pharmacovigilance system is an ambitious project that
                should involve a long-term perspective and the engagement of
                national health workers and other stakeholders at all levels.
                Continuity and perseverance are essential to achieve a solid ADR
                reporting system, improving patient safety, drug efficacy and
                adherence to treatment."

# metadata.dc.relation.ispartof[].value
PLoS Neglected Tropical Diseases, 2020, vol 14, num

# metadata.dc.rights[].value
cc by (c) Cortes Serra, Nuria et al, 2020

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Strengthening the Bolivian pharmacovigilance system: New
surveillance strategies to improve care for Chagas disease and
tuberculosis.