# name
malERA: An updated research agenda for characterising the
                reservoir and measuring transmission in malaria elimination and
                eradication

# metadata.dc.contributor.author[].value
malERA Refresh Consultative Panel on Characterising the Reservoir and Measuring Transmission

# metadata.dc.description.abstract[].value
This paper summarises key advances in defining the infectious
                reservoir for malaria and the measurement of transmission for
                research and programmatic use since the Malaria Eradication
                Research Agenda (malERA) publication in 2011. Rapid and
                effective progress towards elimination requires an improved
                understanding of the sources of transmission as well as those at
                risk of infection. Characterising the transmission reservoir in
                different settings will enable the most appropriate choice,
                delivery, and evaluation of interventions. Since 2011, progress
                has been made in a number of areas. The extent of submicroscopic
                and asymptomatic infections is better understood, as are the
                biological parameters governing transmission of sexual stage
                parasites. Limitations of existing transmission measures have
                been documented, and proof-of-concept has been established for
                new innovative serological and molecular methods to better
                characterise transmission. Finally, there now exists a concerted
                effort towards the use of ensemble datasets across the spectrum
                of metrics, from passive and active sources, to develop more
                accurate risk maps of transmission. These can be used to better
                target interventions and effectively monitor progress toward
                elimination. The success of interventions depends not only on
                the level of endemicity but also on how rapidly or recently an
                area has undergone changes in transmission. Improved
                understanding of the biology of mosquito-human and
                human-mosquito transmission is needed particularly in
                low-endemic settings, where heterogeneity of infection is
                pronounced and local vector ecology is variable. New and
                improved measures of transmission need to be operationally
                feasible for the malaria programmes. Outputs from these research
                priorities should allow the development of a set of approaches
                (applicable to both research and control programmes) that
                address the unique challenges of measuring and monitoring
                transmission in near-elimination settings and defining the
                absence of transmission.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pmed.1002452

# metadata.dc.rights[].value
cc by (c) malERA Consultative Panel
on Characterising the Reservoir and Measuring
Transmission, 2017

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
malERA: An updated research agenda for characterising the
                reservoir and measuring transmission in malaria elimination and
                eradication