# name
Natural immune response to Plasmodium vivax alpha-helical coiled
                coil protein motifs and its association with the risk of P.
                vivax malaria

# metadata.dc.description.abstract[].value
Protein alpha-helical coiled coil structures are known to induce
                antibodies able to block critical functions in different
                pathogens. In a previous study, a total of 50 proteins of
                Plasmodium vivax erythrocytic asexual stages containing
                alpha-helical coiled coil structural motifs were identified in
                silico, and the corresponding peptides were chemically
                synthesized. A total of 43 peptides were recognized by naturally
                acquired antibodies in plasma samples from both Papua New Guinea
                (PNG) and Colombian adult donors. In this study, the association
                between IgG antibodies to these peptides and clinical immunity
                was further explored by measuring total IgG antibody levels to
                24 peptides in baseline samples from a longitudinal study of
                children aged 1-3 years (n = 164) followed for 16 months.
                Samples were reactive to all peptides tested. Eight peptides
                were recognized by >50% of individuals, whereas only one
                peptide had < 20% reactivity. Children infected at baseline
                were seropositive to 23/24 peptides. No significant association
                was observed between antibody titers and age or molecular force
                of infection, suggesting that antibody levels had already
                reached an equilibrium. There was a strong association between
                antibody levels to all peptides and protection against P. vivax
                clinical episodes during the 16 months follow-up. These results
                suggest that the selected coiled coil antigens might be good
                markers of both exposure and acquired immunity to P. vivax
                malaria, and further preclinical investigation should be
                performed to determine their potential as P. vivax vaccine
                antigens.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0179863

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Natural immune response to Plasmodium vivax alpha-helical coiled
                coil protein motifs and its association with the risk of P.
                vivax malaria