# name
Adjunctive therapy for severe malaria: a review and critical
                appraisal

# metadata.dc.description.abstract[].value
BACKGROUND: Despite recent efforts and successes in reducing
                the malaria burden globally, this infection still accounts for
                an estimated 212 million clinical cases, 2 million severe
                malaria cases, and approximately 429,000 deaths annually. Even
                with the routine use of effective anti-malarial drugs, the case
                fatality rate for severe malaria remains unacceptably high, with
                cerebral malaria being one of the most life-threatening
                complications. Up to one-third of cerebral malaria survivors are
                left with long-term cognitive and neurological deficits. From a
                population point of view, the decrease of malaria transmission
                may jeopardize the development of naturally acquired immunity
                against the infection, leading to fewer total cases, but
                potentially an increase in severe cases. The pathophysiology of
                severe and cerebral malaria is not completely understood, but
                both parasite and host determinants contribute to its onset and
                outcomes. Adjunctive therapy, based on modulating the host
                response to infection, could help to improve the outcomes
                achieved with specific anti-malarial therapy. RESULTS AND
                CONCLUSIONS: In the last decades, several interventions
                targeting different pathways have been tested. However, none of
                these strategies have demonstrated clear beneficial effects, and
                some have shown deleterious outcomes. This review aims to
                summarize evidence from clinical trials testing different
                adjunctive therapy for severe and cerebral malaria in humans. It
                also highlights some preclinical studies which have evaluated
                novel strategies and other candidate therapeutics that may be
                evaluated in future clinical trials.

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Adjunctive therapy for severe malaria: a review and critical
                appraisal