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Respiratory microbiota and lower respiratory tract disease

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INTRODUCTION: The respiratory airways harbor a complex
                succession of ecological niches with distinct but related
                bacterial communities. Particular challenges of respiratory
                microbiome research have led to limited scientific output
                compared to other human microbiomes. Areas covered: In this
                review, we summarize the current state of knowledge of the
                bacterial respiratory microbiome, with a particular focus on
                associations between the respiratory microbiome and lower
                respiratory tract conditions. Expert commentary: There is
                growing evidence that the respiratory microbiome is associated
                with lower respiratory infectious diseases and related
                conditions. Most respiratory microbiome reports are
                metataxonomic cross-sectional or case-control studies with
                relatively small sample sizes. Large, prospective projects with
                metatranscriptomics or metabolomics approach are needed to
                unravel the effect of the respiratory microbiome on
                health-related conditions. Moreover, standardization in
                sampling, library preparation, sequencing techniques and data
                analysis should be encouraged.

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Expert Review of Anti-Infective Therapy, 2017, vol. 15, num. 7, p. 703-711

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Articles publicats en revistes (ISGlobal)

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Respiratory microbiota and lower respiratory tract disease