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Direct and enantioselective aldol reactions catalyzed by chiral nickel(II) complexes

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A direct and asymmetric aldol reaction of N-acylthiazinanethiones with aromatic aldehydes catalyzed by chiralnickel(II) complexes is reported. The reaction gives thecorresponding O-TIPS-protected anti-aldol adducts in highyields and with remarkable stereocontrol and atom economy.Furthermore, the straightforward removal of the achiralscaffold provides enantiomerically pure intermediates ofsynthetic interest, which involve precursors for anti-a-amino-b-hydroxy anda,b-dihydroxy carboxylic derivatives. Theoret-ical calculations explain the observed high stereocontrol.

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Angewandte Chemie-International Edition, 2021, vol. 60, num. 28, p. 15307-15312

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Articles publicats en revistes (Química Inorgànica i Orgànica)

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Direct and enantioselective aldol reactions catalyzed by chiral nickel(II) complexes