# name
Aflibercept for Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia: A Case Report.

# metadata.dc.description.abstract[].value
Herein, we present the first described hereditary hemorrhagic telangiectasia (HHT) pa-  tient treated with aflibercept for severe GI involvement after tachyphylaxis to bevacizumab, with  promising results. HHT is a rare genetic disease characterized by systemic vascular malformations.  Gastrointestinal telangiectasia is one of the major involvements that can produce chronic severe  iron-deficiency anemia. Nowadays, support treatment with iron replacement therapy, red blood  cell transfusions, and antiangiogenic drugs—mainly bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF)—are the main therapeutic options for this complication.  The evidence of alternative drugs in patients with failure to this approach, such as tachyphylaxis to bevacizumab, is scarce. Aflibercept is a VEGF inhibitor with antiangiogenic properties approved for the treatment of different types of cancer and ocular neovascularization diseases.

# metadata.dc.rights[].value
cc-by (c) Villanueva, Bernat et al., 2023

# metadata.dc.source[].value
Articles publicats en revistes (Ciències Clíniques)

# metadata.dc.title[].value
Aflibercept for Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia: A Case Report.