# name
Immunosuppressive and angiogenic cytokine profile associated
                with Bartonella bacilliformis infection in post-outbreak and
                endemic areas of Carrion's disease in Peru

# metadata.dc.description.abstract[].value
Analysis of immune responses in Bartonella bacilliformis
                carriers are needed to understand acquisition of immunity to
                Carrion's disease and may allow identifying biomarkers
                associated with bacterial infection and disease phases. Serum
                samples from 144 healthy subjects from 5 villages in the North
                of Peru collected in 2014 were analyzed. Four villages had a
                Carrion's disease outbreak in 2013, and the other is a
                traditionally endemic area. Thirty cytokines, chemokines and
                growth factors were determined in sera by fluorescent bead-based
                quantitative suspension array technology, and analyzed in
                relation to available data on bacteremia quantified by RT-PCR,
                and IgM and IgG levels measured by ELISA against B.
                bacilliformis lysates. The presence of bacteremia was associated
                with low concentrations of HGF (p = 0.005), IL-15 (p = 0.002),
                IL-6 (p = 0.05), IP-10 (p = 0.008), MIG (p = 0.03) and
                MIP-1alpha (p = 0.03). In multi-marker analysis, the same and
                further TH1-related and pro-inflammatory biomarkers were
                inversely associated with infection, whereas angiogenic
                chemokines and IL-10 were positively associated. Only EGF and
                eotaxin showed a moderate positive correlation with bacteremia.
                IgM seropositivity, which reflects a recent acute infection, was
                associated with lower levels of eotaxin (p = 0.05), IL-6 (p =
                0.001), and VEGF (p = 0.03). Only GM-CSF and IL-10
                concentrations were positively associated with higher levels of
                IgM (p = 0.01 and p = 0.007). Additionally, IgG seropositivity
                and levels were associated with high levels of angiogenic
                markers VEGF (p = 0.047) and eotaxin (p = 0.006), respectively.
                Our findings suggest that B. bacilliformis infection causes
                immunosuppression, led in part by overproduction of IL-10. This
                immunosuppression probably contributes to the chronicity of
                asymptomatic infections favoring B. bacilliformis persistence in
                the host, allowing the subsequent transmission to the vector. In
                addition, angiogenic markers associated with bacteremia and IgG
                levels may be related to the induction of endothelial cell
                proliferation in cutaneous lesions during chronic infections,
                being possible candidate biomarkers of asymptomatic infections.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pntd.0005684

# metadata.dc.relation.ispartof[].value
PLoS Neglected Tropical Diseases, 2017, vol. 11, num. 6, p.
                e0005684

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Immunosuppressive and angiogenic cytokine profile associated
                with Bartonella bacilliformis infection in post-outbreak and
                endemic areas of Carrion's disease in Peru