# name
An Antibody Screen of a Plasmodium vivax Antigen Library
                Identifies Novel Merozoite Proteins Associated with Clinical
                Protection

# metadata.dc.description.abstract[].value
BACKGROUND: Elimination of Plasmodium vivax malaria would be
                greatly facilitated by the development of an effective vaccine.
                A comprehensive and systematic characterization of antibodies to
                P. vivax antigens in exposed populations is useful in guiding
                rational vaccine design. METHODOLOGY/PRINCIPAL FINDINGS: In this
                study, we investigated antibodies to a large library of P. vivax
                entire ectodomain merozoite proteins in 2 Asia-Pacific
                populations, analysing the relationship of antibody levels with
                markers of current and cumulative malaria exposure, and
                socioeconomic and clinical indicators. 29 antigenic targets of
                natural immunity were identified. Of these, 12
                highly-immunogenic proteins were strongly associated with age
                and thus cumulative lifetime exposure in Solomon Islanders
                (P<0.001-0.027). A subset of 6 proteins, selected on the
                basis of immunogenicity and expression levels, were used to
                examine antibody levels in plasma samples from a population of
                young Papua New Guinean children with well-characterized
                individual differences in exposure. This analysis identified a
                strong association between reduced risk of clinical disease and
                antibody levels to P12, P41, and a novel hypothetical protein
                that has not previously been studied, PVX_081550 (IRR 0.46-0.74;
                P<0.001-0.041). CONCLUSION/SIGNIFICANCE: These data emphasize
                the benefits of an unbiased screening approach in identifying
                novel vaccine candidate antigens. Functional studies are now
                required to establish whether PVX_081550 is a key component of
                the naturally-acquired protective immune response, a biomarker
                of immune status, or both.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pntd.0004639

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PLoS Neglected Tropical Diseases, 2016, vol. 10, num. 5, p.
                e0004639

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
An Antibody Screen of a Plasmodium vivax Antigen Library
                Identifies Novel Merozoite Proteins Associated with Clinical
                Protection