# name
Identifying Immune Correlates of Protection Against Plasmodium
                falciparum Through a Novel Approach to Account for Heterogeneity
                in Malaria Exposure

# metadata.dc.description.abstract[].value
Background: A main criterion to identify malaria vaccine
                candidates is the proof that acquired immunity against them is
                associated with protection from disease. The age of the studied
                individuals, heterogeneous malaria exposure, and assumption of
                the maintenance of a baseline immune response can confound these
                associations. Methods: Immunoglobulin G/immunoglobulin M (IgG/
                IgM) levels were measured by Luminex(R) in Mozambican children
                monitored for clinical malaria from birth until 3 years of age,
                together with functional antibodies. Studied candidates were
                pre-erythrocytic and erythrocytic antigens, including
                EBAs/PfRhs, MSPs, DBLs, and novel antigens merely or not
                previously studied in malaria-exposed populations. Cox
                regression models were estimated at 9 and 24 months of age,
                accounting for heterogeneous malaria exposure or limiting
                follow-up according to the antibody's decay. Results:
                Associations of antibody responses with higher clinical malaria
                risk were avoided when accounting for heterogeneous malaria
                exposure or when limiting the follow-up time in the analyses.
                Associations with reduced risk of clinical malaria were found
                only at 24 months old, but not younger children, for IgG breadth
                and levels of IgG targeting EBA140III-V, CyRPA, DBL5epsilon and
                DBL3x, together with C1q-fixation activity by antibodies
                targeting MSP119. Conclusions: Malaria protection correlates
                were identified, only in children aged 24 months old when
                accounting for heterogeneous malaria exposure. These results
                highlight the relevance of considering age and malaria exposure,
                as well as the importance of not assuming the maintenance of a
                baseline immune response throughout the follow-up. Results may
                be misleading if these factors are not considered.

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a:
                http://dx.doi.org/10.1093/cid/cix837

# metadata.dc.relation.ispartof[].value
Clinical Infectious Diseases, 2018, vol. 66, num. 4, p. 586-593

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Identifying Immune Correlates of Protection Against Plasmodium
                falciparum Through a Novel Approach to Account for Heterogeneity
                in Malaria Exposure