# name
Early age exposure to moisture damage and systemic inflammation
                at the age of 6 years

# metadata.dc.description.abstract[].value
Cross-sectional studies have shown that exposure to indoor
                moisture damage and mold may be associated with subclinical
                inflammation. Our aim was to determine whether early age
                exposure to moisture damage or mold is prospectively associated
                with subclinical systemic inflammation or with immune
                responsiveness in later childhood. Home inspections were
                performed in children's homes in the first year of life. At age
                6 years, subclinical systemic inflammation was measured by serum
                C-reactive protein(CRP) and blood leucocytes and immune
                responsiveness by ex vivo production of interleukin
                1-beta(IL-1beta), IL-6 and tumor necrosis
                factor-alpha(TNF-alpha) in whole blood cultures without
                stimulation or after 24h stimulation with phorbol 12-myristate
                13-acetate and ionomycin(PI), lipopolysaccharide(LPS) or
                peptidoglycan(PPG) in 251 to 270 children. Moisture damage in
                child's main living areas in infancy was not significantly
                associated with elevated levels of CRP or leucocytes at 6 years.
                In contrast, there was some suggestion for an effect on immune
                responsiveness, as moisture damage with visible mold was
                positively associated with LPS-stimulated production of
                TNF-alpha and minor moisture damage was inversely associated
                with PI-stimulated IL-1beta. While early life exposure to mold
                damage may have some influence on later immune responsiveness,
                it does not seem to increase subclinical systemic inflammation
                in later life. This article is protected by copyright. All
                rights reserved.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1111/ina.12454

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Early age exposure to moisture damage and systemic inflammation
                at the age of 6 years