# name
A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children

# metadata.dc.description.abstract[].value
BACKGROUND: Attention function filters and selects behaviorally
                relevant information. This capacity is impaired in some
                psychiatric disorders and has been proposed as an endophenotype
                for Attention-Deficit/Hyperactivity Disorder; however, its
                genetic basis remains largely unknown. This study aimed to
                identify single nucleotide polymorphism (SNPs) associated with
                attention function. MATERIALS AND METHODS: The discovery sample
                included 1655 children (7-12 years) and the replication sample
                included 546 children (5-8 years). Five attention outcomes were
                assessed using the computerized Attentional Network Test (ANT):
                alerting, orienting, executive attention, Hit Reaction time
                (HRT) and the standard error of HRT (HRTSE). A Genome-wide
                Association Study was conducted for each outcome. Gene set
                enrichment analyses were performed to detect biological pathways
                associated with attention outcomes. Additional neuroimaging
                analyses were conducted to test neural effects of detected SNPs
                of interest. RESULTS: Thirteen loci showed suggestive evidence
                of association with attention function (P<10-5) in the
                discovery sample. One of them, the rs4321351 located in the PID1
                gene, was nominally significant in the replication sample
                although it did not survive multiple testing correction.
                Neuroimaging analysis revealed a significant association between
                this SNP and brain structure and function involving the
                frontal-basal ganglia circuits. The mTOR signaling and Alzheimer
                disease-amyloid secretase pathways were significantly enriched
                for alerting, orienting and HRT respectively (FDR<5%).
                CONCLUSION: These results suggest for the first time the
                involvement of the PID1 gene, mTOR signaling and Alzheimer
                disease-amyloid secretase pathways, in attention function during
                childhood. These genes and pathways have been proposed to play a
                role in neuronal plasticity, memory and neurodegenerative
                disease.

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Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0163048

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
A Genome-Wide Association Study of Attention Function in a Population-Based Sample of Children