# name
Enantioselective synthesis of the ethyl analog of the marine alkaloid haliclorensin C

# metadata.dc.description.abstract[].value
The enantioselective synthesis (3.7% overall yield in nine steps from 2) and biological screening of the ethyl analog of the macrocyclic marine alkaloid haliclorensin C (compound 5) are reported. Amino alcohol 3, generated by a LiNH2BH3-promoted reductive ring-opening/debenzylation sequence from phenylglycinol-derived lactam 2, was used as the starting chiral linear building block. Incorporation of the undecene chain via the nosyl derivative 12, methylenation of the pentanol moiety, and a ring-closing metathesis are the key steps of the synthesis.

# metadata.dc.rights[].value
cc-by (c) Guignard, Guillaume Michel Pablo et al., 2019

# metadata.dc.source[].value
Articles publicats en revistes (Farmacologia, Toxicologia i Química Terapèutica)

# metadata.dc.title[].value
Enantioselective synthesis of the ethyl analog of the marine alkaloid haliclorensin C