# name
Effects of HIV infection on maternal and neonatal health in
                southern Mozambique: A prospective cohort study after a decade
                of antiretroviral drugs roll out

# metadata.dc.description.abstract[].value
INTRODUCTION: The HIV epidemic is concentrated in sub-Saharan
                Africa. However, limited information exists on its impact on
                women and infant's health since the introduction of
                antiretroviral drugs in this region, where health resources are
                often scarce. METHODS: The effect of HIV infection on maternal
                health, birth outcomes and infant health was analysed in two
                contemporary cohorts of HIV-uninfected and HIV-infected pregnant
                women from southern Mozambique. Pregnant women attending the
                first antenatal care visit were followed until one month after
                delivery. Antiretroviral therapy was administered based on CD4+T
                cell count and clinical stage. Maternal and neonatal morbidity
                and mortality, as well as pregnancy outcomes were assessed by
                mother's HIV status. RESULTS: A total of 1183 HIV-uninfected and
                561 HIV-infected pregnant women were enrolled. HIV-infected
                women were more likely to have anaemia both at the first
                antenatal care visit and at delivery than HIV-uninfected women
                (71.5% versus 54.8% and 49.4% versus 40.6%, respectively,
                p<0.001). Incidence of hospital admissions during pregnancy
                was increased among HIV-infected women (RR, 2.04, [95%CI, 1.45;
                2.86]; p<0.001). At delivery, 21% of HIV-infected women
                reported being on antiretroviral therapy, and 70% having
                received antiretroviral drugs for prevention of mother to child
                transmission of HIV. The risk of stillbirths was doubled in
                HIV-infected women (RR, 2.16 [95%CI 1.17; 3.96], p = 0.013).
                Foetal anaemia was also increased among infants born to
                HIV-infected women (10.6% versus 7.3%, p = 0.022). No
                differences were found in mean birth weight, malaria,
                prematurity and maternal and neonatal deaths between groups.
                CONCLUSIONS: HIV infection continues to be associated with
                significant maternal morbidity and poor neonatal health
                outcomes. Efforts should urgently be made to identify the
                barriers that impede improvements on the devastating effects of
                HIV in African women and their infants. TRIAL REGISTRATION:
                ClinicalTrials.gov NCT 00811421.

# metadata.dc.relation.isformatof[].value
Reproducció del document publicat a:
                http://dx.doi.org/10.1371/journal.pone.0178134

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Effects of HIV infection on maternal and neonatal health in
                southern Mozambique: A prospective cohort study after a decade
                of antiretroviral drugs roll out