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Personality changes in patients with refractory epilepsy after surgical treatment: A systematic review

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Purpose
We aimed to conduct a systematic review to evaluate the personality changes in adult patients with drug-resistant epilepsy following surgical treatment.
Methods
A systematic review was conducted using the Preferred Reporting Items of Systematic Reviews and MetaAnalyses (PRISMA) statement. We searched PubMed, Medline databases, and the Cochrane Controlled Trials Register, with search terms ‘personality’, ‘epilepsy’, and ‘surgery’.
Results
Eleven studies were selected. In 7 out of 11 studies, personality changes were more adaptive, with patients experiencing decreased neuroticism, impulsivity, hypochondriasis, psychasthenia. One study showed increased emotional lability. The remainder of the studies showed no changes in personality dimensions.
Changes in personality differed according to the localization of the epileptogenic area, depended on seizure status after treatment and duration of follow-up. Seizure freedom as an outcome of surgical treatment influenced the existence of personality changes, and their severity. Adaptive personality changes could be seen from early follow-up assessments even in patients who were not seizure-free, though further follow-ups showed that improvements after 1–2 years were specific to seizure-free patients.

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Seizure - European Journal of Epilepsy, 2021, vol. 85, p. 95-101

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Articles publicats en revistes (Fonaments Clínics)

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Personality changes in patients with refractory epilepsy after surgical treatment: A systematic review