# name
Lewis-acid-promoted selective isomerization of oxetanes. New synthetic approach towards γ-chiral alcohols

# metadata.dc.description[].value
Treballs Finals de Grau de Química, Facultat de Química, Universitat de Barcelona, Any: 2019, Tutors: Antoni Riera Escalé, Albert Cabré Montesinos

# metadata.dc.description.abstract[].value
The synthesis of enantiomerically pure compounds is one of the main challenges in organic synthesis. Particularly, γ-chiral alcohols are a valuable chemical motif and a useful building block, especially in the pharmaceutical industry. Even though there are several synthetic methodologies already studied, they offer poor atom economy reactions and there is a need of separation steps, consequently lowering the final yield. For this reason, a new approach would be highly desired.
Most promising approaches undergo isomerization reactions that are highly atom economy efficient and generate low to no residues. Still there is not a selective procedure to the isomerization of oxetanes.
In this work, a new general and greener synthetic pathway has been developed. This new approach is based on the Lewis-acid-promoted selective isomerization of oxetane rings.
Afterwards, the correspondent olefin is subjected to an asymmetric hydrogenation using iridiumbased
catalysts.
A standard substrate has been tested in order to optimize the methodology. Finally, a broad scope of  substrates has been studied to generalize the process

# metadata.dc.title[].value
Lewis-acid-promoted selective isomerization of oxetanes. New synthetic approach towards γ-chiral alcohols

# metadata.dc.title.alternative[].value
Isomerització selectiva d’oxetans induïda per àcid de Lewis. Nou enfoc sintètic cap a alcohols γ-quirals