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Chemical rewiring of ubiquitination by degraders and their selectivity routes

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Ubiquitination is an essential process that curtails cellular levels of damaged and redundant proteins. Chemical biologists have harnessed this natural system to induce the degradation of disease-relevant proteins. We reflect here on the potential of ‘degraders’ for targeted selectivity, and discuss the role of computer-aided drug design in shaping future advances.

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Nature Structural & Molecular Biology, 2024, vol. 31, p. 205-207

# metadata.dc.source[].value
Articles publicats en revistes (Institut de Recerca Biomèdica (IRB Barcelona))

# metadata.dc.title[].value
Chemical rewiring of ubiquitination by degraders and their selectivity routes