# name
Whole genome sequencing to evaluate the resistance landscape
                following antimalarial treatment failure with
                fosmidomycin-clindamycin

# metadata.dc.description.abstract[].value
Novel antimalarial therapies are needed in the face of emerging
                resistance to artemisinin combination therapies. A previous
                study found a high cure rate in Mozambican children with
                uncomplicated Plasmodium falciparum malaria 7 days post
                treatment with a fosmidomycin-clindamycin combination. However,
                28-day cure rates were low (45.9%), due to parasite
                recrudescence. We sought to identify any genetic changes
                underlying parasite recrudescence. To this end, we utilized a
                selective whole genome amplification method to amplify parasite
                genomes from blood spot DNA samples. Parasite genomes from
                pre-treatment and post-recrudescence samples were subjected to
                whole genome sequencing to identify nucleotide variants. We find
                that our data do not support the existence of a genetic change
                responsible for recrudescence following fosmidomycin-clindamycin
                treatment. Additionally, we find that previously described
                resistance alleles for these drugs do not represent biomarkers
                of recrudescence. Future studies should continue to optimize
                fosmidomycin combinations for use as antimalarial therapies.

# metadata.dc.relation.isformatof[].value
Versió postprint del document publicat a:
                http://dx.doi.org/10.1093/infdis/jiw304

# metadata.dc.relation.ispartof[].value
The Journal of Infectious Diseases, 2016,

# metadata.dc.source[].value
Articles publicats en revistes (ISGlobal)

# metadata.dc.title[].value
Whole genome sequencing to evaluate the resistance landscape
                following antimalarial treatment failure with
                fosmidomycin-clindamycin