# name
Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives

# metadata.dc.description.abstract[].value
A new series of glycyrrhetinic acid derivatives has been synthesized via the introduction of different heterocyclic rings conjugated with an α,β-unsaturated ketone in its ring A. These new compounds were screened for their antiproliferative activity in a panel of nine human cancer cell lines. Compound 10 was the most active derivative, with an IC50 of 1.1 µM on Jurkat cells, which is 96-fold more potent than that of glycyrrhetinic acid, and was 4-fold more selective toward that cancer cell line. Further biological studies performed in Jurkat cells showed that compound 10 is a potent inducer of apoptosis that activates both the intrinsic and extrinsic pathways.

# metadata.dc.rights[].value
cc-by (c) Alho, Daniela P.S. et al., 2019

# metadata.dc.source[].value
Articles publicats en revistes (Bioquímica i Biomedicina Molecular)

# metadata.dc.title[].value
Synthesis and antiproliferative activity of novel heterocyclic Glycyrrhetinic acid derivatives