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Adapting cord blood collection and banking Standard Operating Procedures for HLA-homozygous induced Pluripotent Stem Cells production and banking for clinical application

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In this article, we will discuss the main aspects to be considered to define standard operation procedures (SOPs) for the creation of an induced pluripotent stem cell (iPSC) bank using cord blood (CB)-or similar cell type-bank guidelines for clinical aims. To do this, we adapt the pre-existing SOP for CB banking that can be complementary for iPSCs. Some aspects of iPSC manufacturing and the particular nature of these cells call for special attention, such as the potential multiple applications of the cells, proper explanation to the donor for consent of use, the genomic stability and the risk of genetic privacy disclosure. Some aspects of the iPSC SOP are solidly established by CB banking procedures, other procedures have good consensus in the scientific and medical community, while others still need to be further debated and settled. Given the international sharing vocation of iPSC banking, there is an urgent need by scientists, clinicians and regulators internationally to harmonize standards and allow future sample interchange between many iPSC bank initiatives that are springing up worldwide.

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Journal of Clinical Medicine, 2019, vol. 8, num. 4, p. 476

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cc-by (c) Álvarez Palomo, Ana Belén et al., 2019

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Articles publicats en revistes (Cirurgia i Especialitats Medicoquirúrgiques)

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Adapting cord blood collection and banking Standard Operating Procedures for HLA-homozygous induced Pluripotent Stem Cells production and banking for clinical application