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Evidence of association of the NLRP1 gene with giant cell arteritis

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Recent studies have focused attention on the involvement of NLRP1 to confer susceptibility for extended autoimmune/inflammatory disorders, being considered a common risk factor in autoimmunity. NLRP1 provides a scaffold for the assembly of the inflammasome that activates caspases 1 and 5, required for processing and activation of the proinflammatory cytokines interleukin 1β (IL-1β), IL-18 and IL-33 and promoting inflammation.

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Annals of the Rheumatic Diseases, 2013, vol. 72, num. 4, p. 628-630

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Articles publicats en revistes (Ciències Clíniques)

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Evidence of association of the NLRP1 gene with giant cell arteritis