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ERK-mediated mechanochemical waves direct collective cell polarization

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During collective cell migration, directional information is transmitted from a leading edge to the follower cells as a form of ERK activation waves. Hino et al. demonstrate that a mechanochemical feedback loop coupling cell deformation and ERK activation enables sustained propagation of the directional information over a tissue-scale expanse.

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Developmental Cell, 2020, vol. 53, num. 6

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Articles publicats en revistes (Institut de Bioenginyeria de Catalunya (IBEC))

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ERK-mediated mechanochemical waves direct collective cell polarization