# name
A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars

# metadata.dc.description.abstract[].value
An efficient method for the preparation of siRNAs modified with ribo-like North bicyclo[3.1.0]hexane pseudosugars is described. The combined use of 2'-O-(2-cyanoethoxymethyl) (CEM) and 2'-O-TBDMS protection was successfully employed for RNA synthesis with the added advantage that both groups were efficiently removed in a single step. The resulting North ribo-methanocarba-modified siRNAs are compatible with the intracellular RNAi machinery and can mediate specific degradation of target mRNA.

# metadata.dc.source[].value
Articles publicats en revistes (Química Inorgànica i Orgànica)

# metadata.dc.title[].value
A direct, efficient method for the preparation of siRNAs containing ribo like North [3.1.0]hexane pseudosugars